purines and pyrimidines nucleotides - What Is Gout?
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What Is Gout?

Gout is an extremely painful disease and can cause immense discomfort apart from complications like kidney stones and the like. Unfortunately, there is no established cure for gout. The best means of thwarting gout attacks is prevention. These insidious attacks occur when you will be least expecting it, sometimes while you are asleep.


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It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

5. Vitamin C - You probably have a Vitamin C supplement in your cupboard for keeping your immune system healthy. However, did you know that doctors are not prescribing Vitamin C tablets for gout attacks? It is believed that ascorbic acid actually aids the body in flushing out uric acid. We suggest starting at 1 gram per day and increasing it weekly until you reach 4 grams.

The most commonly afflicted areas of gout include the big toes and the joints in feet, ankles, knees, hands, wrists, arms, elbows, and bursas, the ligaments and tendons around these joints; and, in extreme cases, shoulders, necks, hips and spine.

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Gout attacks typically set in between midnight and 2 a.m. and are more frequent during the spring. The initial attacks may wane automatically within a few days even without treatment, as the crystals become encrusted by certain proteins that prevent their recognition by the immune system as non-self particles. However, gout may resurface even after years, and in due course of time the frequency of the attacks gradually increases. Ultimately, the problem becomes a persistent one and in chronic cases, can cause permanent distortion of the affected joints.

Natural health works because it treats the problem (uric acid) and not the symptoms (pain, inflammation, and swelling). 5 Alternative Remedies for Gout

For more information about causes of gout please review http://www.gout-info-center.com/gout-diet.htm or even http://www.gout-info-center.com/foods-that-cause-gout.htm

Though you might experience this often, you can actually be causing severe damage by ignoring the problem or treating your gout with painkillers and anti-inflammatories. Though a common practice in the medical field, using pain killers and anti-inflammatories to treat the gout attacks can often lead to a disfigured joint.

1. Purines and Your Diet - You should be doing everything you can to be at your ideal body weight. Being obese significantly increases your risk of gout. You should also do all you can to avoid purines in food. Typical foods with large amounts of purines are any animal-based food products.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

The second type of gout is chronic gout. In these cases treatment is prescribed in order to prevent acute gout attack from recurring. In many of the cases this means decreasing the uric acid levels. The recommended treatments are xanthine oxidase inhibitors and uricosuric agents. Xanthine oxidase inhibitors such as allopurinol lead to decrease of uric acid levels in the organism. Uricosuric agents are medicines that help kidneys to eliminate the excess of the uric acid produced by the body. As uricosuric agents we can mention probenecid or sulfinpyrazone.

3. Vitamins - Many studies have shown that gout sufferers are typically deficient in vitamins such as A, B5, and E. We recommend you supplement these vitamins to your diet to decrease the formation and advancement of gout.

Cure Gout Today... Guaranteed! This is the tip of the iceberg for your natural gout treatment. Though these simple remedies are a great start, they are only the beginning of your treatment. To discover everything you need to know about curing and preventing gout, please visit our Alternative Remedies for Gout website.

Gout is a problem that in most of the cases occurs suddenly. That is why it is really hard to prevent it. Doctors can only advice for a low alcohol intake and a healthy diet. Only after its occurrence specialists are able to prescribe a treatment. Treatment for gout is prescribed in order to ease the symptoms that usually consist of extreme pain in the affected joints.

Though doctors typically prescribe an anti-inflammatory and a pain killer for gout sufferers, there are many natural health treatments you can to do permanently cure gout. The reason why many doctors are now suggesting alternative remedies for gout is because these natural health remedies work to decrease the amount of uric acid between the joints. Neither painkillers nor anti-inflammatories can do this!

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

Medications should be taken within a short while of the onset; otherwise the attack may get beyond control. If no treatment is administered within the first 12 hours, combating gout becomes near to impossible. If you are a frequent sufferer, do remember to carry necessary medicines wit you wherever you go, even on business or pleasure trips. Do take sufficient rest until the attack completely subsides, overuse of the strained joints may cause irreparable damage. For more tips and info about Gout?, feel free to visit us at: http://www.about-goat.info

 
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"My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY
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Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

We know two types of gout. Acute gout is treated using different medicines such as non-steroidal anti-inflammatory drugs (NSAIDs), colchines and corticosteroids. The NSAIDs are drugs that help easing the pain and have an anti-inflammatory effect. As NSAIDs we have to mention indomethacin, ketoprofen, oxaprozin, diclofenac, ibuprofen, etodolac, naproxen and sulindac. This type of treatment has proved to be the best in preventing gout attacks and easing the symptoms. NSAIDs are recommended for as long as the patient has symptoms and are taken by mouth three or four times a day. NSAIDs assure the easing of symptoms by suppressing the production of fatty acids called prostaglandins that cause the inflammation and pain in gout sufferers.

Colchine is the alternative for NSAIDs. This medicine has been used to treat gout for years. It has benefic effects on reducing and even eliminating the pain caused by gout. Even so this treatment is not recommended for persons who can not tolerate side effects such as diarrhea, nausea, vomiting or abdominal cramps. Colchine is a treatment with benefic effects because it reduces the deposit of uric acid crystals that cause inflammations. An intake of colchine within 24 to 48 hours of the onset of the gout symptoms is believed to have the awaited effect.

Alternative Remedies for Gout

2. Water - Water can literally flush tons of uric acid outside of the body each day. The problem is that most of us don't get enough water. You should be drinking 12 tall glasses of water every day. You will feel healthier in days and you will also notice your gout attacks diminishing.

Why Natural Health Works! Gout most often results when needle-like crystals of uric acid form in the body's connective tissue or lodge themselves in the space between two bones (joints). These uric acid crystals inflame the surrounding area and lead to inflammatory arthritis. This inflammatory arthritis is responsible for the heat, pain, redness, stiffness and swelling that is associated with this disease.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

4. Fruits - As stated earlier, diets lacking certain key vitamins can actually cause gout. However, by eating the right types of fruits with these vitamins can counter-act the effects of gout. We recommend these healthy fruits for your natural treatment: cherries, celery, strawberries, avocados, blueberries and grapes.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

There are many effective alternative remedies for gout and many of them are not even suggested by doctors. If you are suffer the most painful form of arthritis, gout, it is time you begin to prioritize your health and try simple natural health remedies that work by reducing uric acid levels.

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

The third way of treating gout is the use of corticosteroids such as prednisone, prednisolone and triamcinolone. This treatment is prescribed for patients that can not take NSAIDs or colchine, being the third alternative in treating gout. This treatment has benefic effects after steroids are injected into the joint muscle. Afterwards pain is locally relieved.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

It is the middle of the night and you awake to find that your big toe feels as if as been run over by a Mac truck. You turn on the lights to discover that your toe is swollen, red and throbbing from the pain! Though you do not know it, your uric acid levels are off the charts and the uric crystals between your joints are causing the unbearable pain.

Purine is a normal constituent of the human diet. It is metabolized within the body to produce uric acid, which then reacts with the sodium ions present in the system to give mono-sodium urate (MSU). The production of MSU rises with the internal pH of the body. At the biological pH, the MSU exists in the form of insoluble crystals that deposit on the joints of the body. The bodys defense mechanism recognizes these accumulated crystals as foreign invasions and combats them with white blood cells called neutrophils. As a result of this immunologic reaction, sudden inflammation and rubor of the skin develops, along with heat production and tenderness of the affected regions. This is accompanied by excruciating pain as the bodys defense mechanism fights the invading MSU crystals. The symptoms include malaise, fever, chills, increased heart rate, and high blood pressure.

We guarantee our Gout Remedy Report to cure your arthritis completely plus we guarantee that you will be completely satisfied. Our researched reports are step by step and have helped thousands of sufferers treat themselves from the comfort their home. Besides saving money, you will never have to worry about a gout attack again!

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Only in the last ten years has natural health alternative treatments become so popular. Part of the reason is because many people are sick of dealing with the side effects from synthetic medications. Another reason is because research is not showing that many alternative remedies have a surprising legitimacy.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.


 
 
     
 
 





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