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Causes Of Gout

Gout is a painful disease of the joints, which usually affects the big toe first in most people. It is caused by too much uric acid in the blood. Uric acid is formed by the breakdown of chemicals called purines, which can lead to high levels of uric acid and cause many problems such as joint swelling and kidney stones. Normally the uric acid is dissolved in the blood and passes out via the kidneys into the urine but if this does not occur it can build up in the body and cause the crystals to deposit and cause gout.


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These are usually administered together in combination with Steroidal and non-steroidal anti-inflammatory (NSAID) treatments for Gout. A word of caution: Your physician must closely monitor ongoing Gout natural treatment. Many prescription drugs have side effects???and some are potentially fatal if combined.

These are some of the most important factors of risk in gout cases. There are also some other factors, but they are less common.

Unlike natural remedies for Gout, prescription drugs that treat Gout focus on different mechanisms to decrease Uric Acid levels in the blood. Medications called Uricosurics, such as Probenecid, force the secretion of Uric Acid back into the urine removing it from the blood stream, while others inhibit the initial production of Uric Acid (Allopurinol, Cholchicine) in the first place.

Purine is also found in protein-rich foods such as seafood, poultry, organ meats, yeast products, as well as vegetables such as asparagus and mushrooms. Avoid these foods (and alcohol) to help prevent future flares.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

It is 2:00 a.m. You sleep soundly after savoring a scrumptious surf and turf dinner at the best restaurant in town. Suddenly an intense stinging pain caused by the soft cotton sheet resting against your big toe awakens you with a jolt! This could be an acute attack of Gout, the aftermath of a high-protein diet.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

No matter what Gout remedy you opt for, whether in the form of Gout's natural treatments or prescribed drugs, you vow to fight the pain of flare-ups, prevent future attacks and avoid complications such as kidney stones or immobility from chronic degeneration of joints over the span of time.

1. Beverages such as stinging nettle and horsetail tea can help eliminate Uric Acid from the joints 2. Horseradish and parsley juices stimulate elimination of wastes 3. Birch leaf, celery and mustard seeds may also flush out uric acid 4. Herbs such as soothing Devil's Claw, and cleansing Poke Root

As you describe the symptoms to your doctor, he suspects (and tests for) elevated Uric Acid levels in your bloodstream. Once confirmed, your doctor will determine a suitable Gout remedy.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

Some genetic diseases affect the breakdown of uric acid and also cause it to build up. Other causes include exposure to lead, foods high animal protein, some medications, obesity, excess alcohol or foods rich in purines. Some foods that cause gout are organ meats such as liver, brain and kidneys. Other foods include herring, anchovies, peas and dried beans. Alcohol affects the elimination of uric acid especially when taken in excess.

Gender - gender is another risk factor in gout cases, unfortunately one that we have no control over; men are more at risk of developing gout than women are; men who are over twenty years old can develop gout; however, studies have shown that most men had their first gout attack somewhere between the age of thirty five to forty; there are no known case of men who have suffered from a gout attack in their twenties; if you thought that men are the only one who can suffer form gout, then you were wrong; even if this disease is mostly found in men, women can also suffer from gout; after menopause, the level of uric acid rises in women and they can develop gout; however, women mostly have their first gout symptoms around the age of fifty, whereas men can develop them as early as in their thirty' s;

A powerful anti-inflammatory derivative of pineapple called Bromelain has been effective in Gout's acute treatment phase. Vitamin C may be helpful as well, but exercise caution as there are conflicting theories as to the level of therapeutic treatment of Gout.

Age - age is another risk factor associated with got; gout is mostly seen in men who have reached middle age; the peak point of gout is the age of forty; gout is mostly linked with high pressure of blood, obesity, high cholesterol levels and use of alcohol; if older people are affected by gout, then gender does not count; both older men and women can be affected by gout; children are not affected by gout;

Though there is little evidence to conclusively prove it, a small study presented promising information that Uric Acid levels decreased after eating a heaping helping of Bing cherries and other red or blue berries. This is a popular home remedy for lowering Uric Acid as a natural treatment of Gout.

During the acute phase of Gout, be kind to yourself. Stay hydrated by drinking at least 96 ounces of water daily. Keep the TV remote control handy with your feet elevated; avoid weight bearing. Lose the liquor, for it only antagonizes symptoms. Follow appropriate dietary guidelines, and if you do...you can fight the complications that obesity brings to the table.

 
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Immediate pain control is priority in treating acute stages of Gout. Over the counter and prescription Analgesics such as Acetaminophen and Indomethacin, respectively, are effective in fighting pain and inflammation.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

The Route to Natural Remedy for Gout Dietary supplements, vitamins and herbs are natural remedies for Gout. Included are Vitamins E and B complex, Folic Acid and evening primrose oil.

Low carbohydrate diets, especially when very protein rich and with inadequate water intake can also cause gout. A family history of gout may also predispose a person towards getting it.

When in doubt about combining Gout's natural remedy as well as traditional, seek the advice of a medical professional. Below are other natural remedies for Gout to treatment that may prove beneficial for lowering Uric Acid levels and easing discomfort or maintaining urinary/fluid health:

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

As Gout remedy and treatment, he will probably advice medications, dietary and natural remedies for Gout that's got your goat. According to the Centers for Disease Control (CDC) approximately 3.3 million Americans (more men between 30-60 years than women) suffer from Gout and its ill effects. Finding the right combination of treatment and natural remedy for Gout that is safe, effective and reliable can be a challenge.

Gout is not a very common disease and it does not affect anyone. However, there are some factors of risk when it comes to gout. Here are some of the most important risk factors in gout cases: Genetics - studies have shown that almost one of four people who suffer from gout have family history of this medical condition; this is to say that more than fifteen percent of all gout patients, have gout in their family history;

You can opt for either prescribed or natural treatment for Gout or a combination of both. Remember the elevated Uric Acid level in your blood test? Uric Acid is a crystalline substance normally present in urine. It is a by-product of a substance called Purine generated by the normal break down of proteins in our cells. In Gout, Uric Acid is not metabolized properly. It forms crystals that spill into the blood stream and collect within the joint area causing severe pain and inflammation.

Alcohol - another risk factor when it comes to gout is alcohol, mostly the abuse of alcohol; alcohol increases the uric acid level that is responsible for gout; alcohol abuse is mostly related with younger gout patients;

Medications such as diuretics (which help the kidney eliminate more urine) or aspirin cause gout. And people who have had an organ transplant are prone to gout. Patients on numerous medicines should talk to their healthcare provider to see if there are interactions between medicine and if an alternate drug may help. The common vitamin niacin can also trigger gout.

Causes Of Gout provides detailed information on Causes Of Gout, Foods That Cause Gout, Gout, Gout Home Remedy and more. Causes Of Gout is affiliated with Laser Printers.

However, before administering any kind of Gout remedy, first you need to know about the disorder that is ailing you.

Gout Remedy, Its Treatment & Prescription Options Before exploring treatments and natural remedies for Gout, let's visit physiological basics of Gout.

For a natural dietary approach to the treatment of Gout look no further than your own kitchen! Also as Gout's natural remedy there are foods that Gouty arthritis may respond to deliciously.

Obesity - obesity is also a friend of gout; your body weight and the levels of uric acid are highly linked together; obesity is mostly a gout risk factor in men and less in women; if a child is obese then the risk of developing gout when he grows up is increased;

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Dietary regimens that help manage symptoms of Gout include a diet high in complex carbohydrates such as bread, potatoes and pasta, and low in fats and protein. Toss in some fresh fruits and veggies including cabbage, peppers and pineapple along with low-fat dairy and...voila!

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

Gout is a form of hereditary metabolic Arthritis uniquely characterized by searing pain affecting a single joint (usually a great toe, but may be a hand, elbow, or knee) accompanied by redness and warmth of the skin, swelling and inflammation.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

A customized plan awaits your dining pleasure. And possibly, a good night's sleep!

Betty Roberts is the author of Gout-Info.com, a website dedicated to Gout sufferers.


 
 
     
 
 





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