uric acid blood levels - Uric Acid Testing
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Uric Acid Testing

Definition

Uric acid tests are tests that are done to measure the levels of uric acid in blood serum or in urine.

Purpose




Normal results

Blood test

Reference values for blood uric acid vary from laboratory to laboratory but are generally found within the following range: Male: 2.1-8.5 mg/dL; female: 2.0-6.6 mg/dL. Values may be slightly higher in the elderly.


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 Certain foods that are high in purine may increase the patient's levels of uric acid. These include kidneys, liver, sweetbreads, sardines, anchovies, and meat extracts.

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Uric acid is a waste product that results from the breakdown of purine, a nucleic acid. (Nucleic acids are the building blocks of DNA.) Uric acid is made in the liver and excreted by the kidneys. If the liver produces too much uric acid or the kidneys excrete too little, the patient will have too much uric acid in the blood. This condition is called hyperuricemia. Supersaturated uric acid in the urine (uricosuria) can crystallize to form kidney stones that may block the tubes that lead from the kidneys to the bladder (the ureters).

Decreased excretion of uric acid is seen in chronic kidney disease, low thyroid, toxemia of pregnancy, and alcoholism. Patients with gout excrete less than half the uric acid in their blood as other persons. Only 10-15% of the total cases of hyperuricemia, however, are caused by gout.

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The uric acid tests are used to evaluate the blood levels of uric acid for gout and to assess uric acid levels in the urine for kidney stone formation. The urine test is used most often to monitor patients already diagnosed with kidney stones, but it can also be used to detect disorders that affect the body's production of uric acid and to help measure the level of kidney functioning.

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Abnormal results

The critical value for the blood test is a level of uric acid higher than 12 milligrams per deciliter (about 3.4 ounces).

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Key Terms

Fanconi's syndrome
A rare disorder caused by vitamin D deficiency or exposure to heavy metals.
Gout
A metabolic disorder characterized by sudden recurring attacks of arthritis caused by deposits of crystals that build up in the joints due to abnormally high uric acid blood levels. In gout, uric acid may be overproduced, underexcreted, or both.
Hyperuricemia
Excessively high levels of uric acid in the blood, often producing gout.
Purine
A white crystalline substance that is one of the building blocks of DNA. Uric acid is produced when purine is broken down in the body.
Uric acid
A compound resulting from the body's breakdown of purine. It is normally present in human urine only in small amounts.
Uricosuria
Increased levels of uric acid in the urine.
Wilson's disease
A rare hereditary disease marked by the buildup of copper in the liver and brain, causing loss of kidney function.

Further Reading

For Your Information

    Books

  • Laboratory Test Handbook, edited by David S. Jacobs. Cleveland, OH: Lexi-Comp Inc., 1996.
  • Mosby's Diagnostic and Laboratory Test Reference, edited by Kathleen Deska Pagana and Timothy James Pagana. St. Louis: Mosby-Year Book, Inc., 1998.
  • Springhouse Corporation. Handbook of Diagnostic Tests, edited by Matthew Cahill. Springhouse, PA: Springhouse Corporation, 1995.

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Abnormally low uric acid levels may indicate that the patient is taking allopurinol or probenecid for treatment of gout; may be pregnant; or suffers from Wilson's disease or Fanconi's syndrome.

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There is some recent research, which has shown that vitamin C in certain doses may decrease the uric acid level slightly. However it may not be relevant in patients with gout and further details are needed. Another interesting recent research revelation was that meat and seafood intake raised uric acid levels but dairy intake decreased it. Again, what this means for patients who have gout or individuals trying to prevent gout is unclear. Surprisingly, recent analyses have shown that moderate protein or even purine-rich vegetables was not associated with an increased risk of gout.

Increased production of uric acid may result from eating foods that are high in purine. Increased uric acid levels due to overproduction may also be caused by gout, by a genetic disorder of purine metabolism, or by metastatic cancer, destruction of red blood cells, leukemia, or cancer chemotherapy.

NSAIDs can cause side-effects including stomach pain, bleeding and ulcers. And corticosteroid (prednisone) can cause more serious side-effects including thinning of bones, poor wound healing and decreased ability to fight infection. It would be recommended to avoid corticosteroid because of severity of the side-effects.

The purines get converted to uric acid but if they accumulate in excess they will cause gout. The uric acid crystals, which form will irritate the lining of joints such as the one in the big toe. This leads to inflammation and pain and swelling at the joint. Cutting back on the amount of foods that cause gout or avoiding them is a good idea if someone has gout, however, always remember to get an adequate and balanced diet. Alcohol affects the removal of uric acid from the body and too much alcohol can trigger gout. Low carbohydrate diets, which are rich in protein, can also trigger gout. People often forget to drink enough water especially in winter and this needs to be kept in mind if they are on a low carbohydrate diet. With the use of medications there is less of a need for a drastic dietary change but avoiding or limiting certain foods will help reduce the severity of attacks and may help people who have difficulty with medications that treat gout.

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The laboratory should also be notified if the patient has had recent x-ray tests requiring contrast dyes. These chemicals increase uric acid levels in urine and decrease them in blood.

Risks

Risks for the blood test are minimal, but may include slight bleeding from the puncture site, a small bruise or swelling in the area, or fainting or feeling lightheaded.

For instance, think of the flu! How does your body feel when you have the flu? Exactly, it hurts all over. The whole body is working together as one organism that is affected by all its parts. Natural treatment remedies work by giving the body the proper means to heal the ailment. In the case of gout, various fruits, vitamins and a cooking ingredient act to neutralize the uric acid that causes current and future gout attacks. Along with curing the pain, the water soluble fiber from the fruit also cause the body to flush itself naturally. Leaving your whole body to benefit from the gout natural treatment.

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Precautions

Blood test

Patients scheduled for a blood test for uric acid should be checked for the following medications: loop diuretics (Diamox, Bumex, Edecrin, or Lasix); ethambutol (Myambutol); vincristine (Oncovin); pyrazinamide (Tebrazid); thiazide diuretics (Naturetin, Hydrex, Diuril, Esidrix, HydroDiuril, Aquatensen, Renese, Diurese); aspirin (low doses); acetaminophen (Tylenol); ascorbic acid (vitamin C preparations); levodopa (Larodopa); or phenacetin. These drugs can affect test results.

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Urine test

Patients should be checked for the following medications before the urine test: diuretics, aspirin, pyrazinamide (Tebrazid), phenylbutazone, probenecid (Benemid), and allopurinol (Lopurin). If the patient needs to continue taking these medications, the laboratory should be notified.

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Description

The uric acid blood test is performed on a sample of the patient's blood, withdrawn from a vein into a vacuum tube. The procedure, which is called a venipuncture, takes about five minutes. The urine test requires the patient to collect all urine voided over a 24-hour period, with the exception of the very first specimen. The patient keeps the specimen container on ice or in the refrigerator during the collection period.

Urine test

Reference values for 24-hour urinary uric acid vary from laboratory to laboratory but are generally found within the following range: 250-750 mg/24 hours.

Foods that cause gout are rich in a chemical called purines. These foods include organ meats such as liver, brain, kidneys and sweetbreads. Other foods include anchovies, herring, dried peas and beans.

Preparation

The uric acid test requires either a blood or urine sample. For the blood sample, the patient should be fasting (nothing to eat or drink) for at least eight hours before the test. The urine test for uric acid requires a 24-hour urine collection. The urine test does not require the patient to fast or cut down on fluids. Some laboratories encourage patients to drink plenty of fluids during the collection period.

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Most fruits and vegetables are high in potassium. Potassium regulates electrolytes in the body and has the ability to get rid of uric acid crystals from the blood. Potassium-rich fruits are bananas, avocados, apricots and cantaloupe. High-potassium vegetables include spinach, potatoes, asparagus, beets and pumpkin. Purines are mostly found in foods which are high in protein and fat...


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