cherry juice and gout - New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
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New Gout Drugs ??? Pegloticase Continues Its Hopeful Path

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.


5. Medications: Are you currently on any of the following medications which may cause gout: diuretics (for hypertension, edema and heart disease), anti-inflammatory medicines with salicylic acid (such as aspirin), niacin (also called nicotinic acid) and a few others. It is noted, please do not stop taking these medications before talking with your doctor.


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 HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

knee, the ankle joints, or the big toe. In most cases, gout arthritis gives attacks in the night but will move on to other parts of the day. Many people who experience gout arthritis will say that the pain feels like a crushing or

1. Lifestyle: From eating to drinking to weight, your lifestyle - particularly your diet - can greatly affect your chances of getting gout. 2. Alcohol: More than two drinks a day for men and one drink a day for women - can quickly lead to gout. Especially, stay away from beer.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

uric acid like it should be. Many researchers are still working on why this happens because as of right now, the cause is unknown. But what is know is that males are more common to get this, along with people who drink a lot of

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

Common Symptoms And Treatment A person who has gout arthritis may notice that only one or two joints are affected and those usually seem to be the

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

6. Family History: One out of every four people afflicted with gout have a family history with gout. 7. Age and Sex: Men are most often affected with gout as well as women who have reached menopause. Men typically develop gout between the ages of 30 and 50.

Alcohol and certain foods can trigger a gout attack. Events such as strokes, heart attacks or surgery may also cause gout. Gout is strongly associated with obesity, hypertension, hyperlipidemia and diabetes. Because of genetic factors, gout tends to run in some families. A variety of treatments can help you manage your gout. Traditionally treatment for acute gout has consisted of colchicine , which can be effective if given early in the attack. Gout often is treated with nonsteroidal anti-inflammatories (NSAIDs) such as naproxen (e.g., Anaprox, Naprosyn) and indomethacin (e.g., Indocin), usually for 3-7 days.

Who's at risk for Gout? Why could you be suffering from the horrific pain of gout? There could be various factors but here is what typically increases uric acid in the blood causing the gout:

3. Overweight: People who weigh 30 pounds or more than their model weight risk getting gout simply because there is more tissue available for breaking down the uric acid. Diets rich in purine food can also increase your chances for gout. For more information, please check out our link below.

4. Medical Conditions: Various medical conditions can also increase your chances of gout. Do you have any of the following: high blood pressure (hypertension), diabetes, hyperlipidemia (high levels of fat or cholesterol in blood), arteriosclerosis (narrowing of the arteries), recent surgery or bed rest, and recent chemotherapy?

Gout is one of the most common forms of arthritis (joint inflammation). Gout is condition that results from crystals of uric acid depositing in tissues of the body. Gout usually affects the first metatarsal phalangeal joint of the big toe (hallux) or the ankle joints. Gout most often affects the big toe but can also affect the ankle, knee, foot, hand, wrist and elbow. Approximately one million people in the United States suffer from attacks of gout. Gout is nine times more common in men than in women. It predominantly attacks males after puberty, with a peak age of 75. In women, gout attacks usually occur after menopause.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

There seems that there is a lot of confusion as to what gout arthritis, or gouty arthritis, is because so many people just think that arthritis is arthritis and that all types are the same. But that is simply not the case at

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

keep the patient on a daily dose of the medication to help prevent future painful attacks from the gout arthritis. When treated properly, many people can live their daily lives without second thought and the painful attacks will

throbbing in the joints and for some people, it is overpowering. The pain usually does last a few days but then will go away and may reappear later down the road without warning. Then again, there are the lucky ones who never go

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

The Cause of Gout To answer what causes gout? We need to understand how uric acid appears in the body. You see, uric acid is actually a byproduct of a very necessary part of your body's normal function. However, gout sufferers often have higher levels of uric acid (called hyperuricemia) caused from the body's inability to break down the uric acid. The uric acid is typically eliminated from the body through the urine. If, however, you suffer from gout, the build up of uric acid crystals can find their way to joint spaces where they will cause painful inflammation that appear as lumps under the skin and can even disrupt the functioning of the kidney and cause the formation of kidney stones. Gout can cause serious damage quickly, it is extremely important that you treat your gout immediately.

 
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People Said About Goutezol Gout Relief
"My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY
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This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

A Home-Remedy for Gout? What would you give to cure your gout symptoms in 2 hours? What would you say if someone guaranteed your gout symptoms would vanish in 2 hours? No more pain, no more stiffness, no more throbbing! Baton Publish, a leading natural health company which specializes in home remedies and natural cures, guarantees a natural cure for gout symptoms in less than 2 hours. This is what one of our readers has to say:

To prevent future attacks, your doctor can prescribe a medicine to reduce uric acid buildup in your blood. Changing the way you eat can help you conduct your gout. Eat a healthy mix of foods so you get the nutrients you need. Limit foods like meat, fish, and beer. Drink plenty of water and other fluids.Life style changes such as limiting alcohol consumption, and limiting meals with meats and fish rich in purines can also be helpful in controlling gout. Weight loss may be very important this condition. You should also avoid certain animal proteins, such as: seafood; liver; kidney; heart; gizzard; sweetbreads; meat extracts; and gravy.

Herbal remedies for gout have become very popular in recent years. There is very little evidence right now that shows alternative therapies are effective for gout. Uricinex is a breakthrough herbal product that we have recently discovered. Blueberries are high in anti-inflammatory compounds called anthocyanins, which help ease the pain of gout. Other herbal treatments that have shown some success include vitamin C - Taking supplemental amounts of vitamin C helps some people to reduce the uric acid in their blood. Taking 2-3 teaspoons of black cherry juice a day helps some people. Cherries are a popular home remedy for gout.

with the inflammation and the swelling of the affected area. Once the medicine has begun, people will notice the pain will decrease within twelve hours and it will be totally gone within forty-eight hours. Doctors may decide to

"Ouch" It's midnight and you are awakened by a horrific pain shooting through your big toe. The throbbing toe is red and swollen and feels as if it's on fire. If you or a loved one can relate to this experience, chances are likely that you suffer from gout. Numerous questions plagued your mind like "Can I survive another night with this pain?"....so we narrowed down your most important questions on gout and answered them! What is gout? What are the symptoms of gout? What causes gout? Am I at risk for gout? Is there a natural treatment for gout? Keep reading to begin the road to recovery! And guess what, it's only 2 hours away!

"Hi, I recently tried your natural remedy for a reoccurring gout episode. I started the remedy on Friday night and by early Saturday my gout symptoms were completely gone! Incredible! I plan to continue with your suggestions"

Now, picture yourself worry-free, pain-free and enjoying life again. You are only two hours away? Please visit our natural treatment for gout website and treat your gout naturally... guaranteed!

all as gout arthritis is very different from other types of arthritis. This type of arthritis is a sudden attack of extreme pain within the joints of the body but mostly in the legs and the feet joints. This typically occurs once

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

Joe Barton writes for Barton Publishing Inc., a leading natural health company specializing in educating people of numerous natural remedies and safe, affordable cures. To discover how thousands have naturally cured the symptoms of gout please click here: Cure your gout now

there is a lot of uric acid that has built up within the joints to cause the pain. Gout arthritis is where there is too much uric acid produced or when the kidney is no longer able to get rid of the

What is gout? Simply put, gout is a form of arthritis that often occurs in the middle of the night. Often labeled the 'disease of kings' gout haunts over 2 million Americans annually. Gout is also known as the most painful types of arthritis. Gout results when needle-like crystals of uric acid form in the body's connective tissue or lodge themselves in the space between two bones or joints. These uric acid crystals inflame the surrounding area and lead to gout's symptoms: Heat, Pain, Redness, Stiffness, Swelling, Arthritis attacks that develop in short time period (e.g., 12-24 hours), and Arthritis Attacks to one joint. Typical joints affected by gout include: elbows, fingers, heels, instep, and wrists. To view some photos of gout sufferers please click our link below. Unfortunately, this is not all of the symptoms. Gout can also cause high blood pressure and kidney stones if left untreated. These symptoms can also be life-threatening if left untreated. But why do I suffer?

alcohol, and women who are postmenopausal. Gout arthritis is also seen in people who already suffer from obesity, kidney disease, sickle cell anemia, and diabetes.

through it again in their lives. There is medication that can be given to those suffering from gout arthritis and that medicine helps the pain along

Understanding what places you at risk of the disease is an important step in taking control of your health and life. Gout can be naturally treated or be deadly in some cases. So that brings up the question, how do you treat gout naturally?

It occurs more frequently in countries that have a high standard of living. The most common sign of gout is a nighttime attack of swelling, tenderness, redness, and sharp pain in your big toe. There may also be the feeling that the skin around the area is stretching or tearing. There seem to be a number of factors that can cause people to develop gout. Some medications can prevent uric acid from leaving the body. Cyclosporine which is a medication used to suppress the body's immune system and prevent rejection after organ transplant, also increases the risk for developing gout. This can cause a build up of uric acid crystals.

only be a distant memory to them.

For more information on arthritis depression and where you can go to get help, please visit my website at http://www.liveer.com/arthritis/


 
 
     
 
 





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